can mantle cell lymphoma be cured | Lymphoma

Lymphoma



Tumors
Summary of the article
Incidence and Causes
Lymphoma Rate
Classification of Lymphomas
Aggressive and indolent lymphomas
Course
Symptoms
Therapy
Summary
Lymphoma is a primary tumor of lymphoid cells. Specifically, for "lymphoma" This means a heterogeneous group of malignant tumours involving lymph nodes and the glandular lymphatic system in general, which also includes B cells, T cells and their precursors.
Incorrectly, the presence of certain cellular and related phenotypic expressions, we tend to confuse lymphoma with leukemia; In reality, the spirit of leukemia is a bone marrow cancer in which cancer cells do not locate in a particular locus, lymphoma ensures the localization of the tumor mass in a specific lymphoid area (present Usually to a given peripheral lymphatic tissue).

Incidence and Causes
Lymphoma has a very high incidence, so you set up one of the most common malignant tumours in the world; Lymphomas represent only 5% of malignant tumours, but also are the fifth cause of cancer deaths.
Unfortunately, 70% of lymphomas cause is unknown; For the remaining 30%, lymphomas may be favored by immunodeficiency (e.g., associated with HIV or as a result of organ transplantation), autoimmune diseases (e.g., rheumatoid arthritis) and bacterial infections ( Helicobacter pillory) and viral (Epstein-Barr which causes Burkitt's lymphoma). Other cancers can trigger lymphomas, as well as radiation and chemicals in general (related to neoplasms only 1% of cases).

Lymphoma Rate
The lymphoma of the spleen, the cancer that occurs mainly in the elderly, it is very difficult to diagnose and more often is underestimated; Normally, lymphoma is linked to the rate thrombocytopenia (amount of circulating platelets less than 150 000/mm3), lymphocytosis, anemia (lymphocytosis associated with anemia) and splenomegaly (excessive spleen growth). Although genetic predisposition affects Sull'eziopatologia lymphomas.

Classification of Lymphomas
In Who Classification, who (World Health Organization) previously refines REAL work performed (acronym for revised Lymphoma European-American), and classifies lymphomas into five broad categories, each of which consists of several Subclasses:

Lymphoma of T-cell precursors;
Lymphoma of mature T lymphocytes and natural killer cells (e.g., leukemia. Large T of granular lymphocytes, lymphomatoid Papulosis, Sèzaty syndrome);
B cell precursors lymphoma (e.g., B cell precursors leukemia);
Lymphoma of mature B lymphocytes (e.g. follicular lymphoma, cutaneous lymphoma, mantle cell lymphoma, Burkit lymphoma);
Hodgkin's lymphoma they belong to: nodular sclerosis, lymphocyte depletion, cellular heterogeneity;
NHL (Ex. for spleen lymphoma).
This classification of lymphomas is the last update in 2008. Before that date, lymphomas were divided according to the dangerousness, the complex division since it makes use of relatively subjective principles: lymphoma could explode in its manifestations in a more or less aggressive manner depending on the Subject. Previous categorizations are therefore unclear, and have caused confusion because the criteria for the recognition of various malignant tumors have doubts and den undefined. The current classification of lymphomas, however, according to cellular, morphological, anatomical and histological parameters, seems indisputable.

Aggressive and indolent lymphomas
In addition the classification of lymphomas is carried out according to the clinical evolution: Stand The mourners of these indolent and aggressive lymphomas. The first, a fast race with an almost immediate weakening of the state of health of the person concerned. If they are not treated quickly lead to death. Fortunately, if it is detected early, aggressive lymphoma can be definitively cured (eg. The majority of lymphomas affecting T-lymphocytes). Indolent lymphomas, however, occur without causing serious injury at the body level, so that patients may not be aware of the tumor for a few years (eg. B lymphocyte tumours). Non-aggressive tumors, though such, present a difficult and complex curative therapy, and the patient finds it difficult to heal completely.

Course
The clinical and pathological results of lymphoma has an almost standardized course: first the tumor affects a specific area, as a single organ, a region rich in lymph nodes or an extra-ganglionic region. Subsequently, the tumor affects several areas, usually located on the same side of the diaphragm; In the next step, lymphoma progresses affecting regions located on both sides of the diaphragm and/or in the spleen. The evolution of maximal lymphoma occurs when the cancer spreads to other organs, metastatizzando.

Symptoms
More info: Symptoms of lymphoma

The symptoms that act as a wake up call for the person concerned may be multiple depending on the lymphoma; Given the multiplicity of lymphomas and the variability of clinical aspects, the symptoms may be different: significant and unexplained decrease in body weight in a few months, excessive sweating and abundant during the night, a Temperature above 38 °c

Therapy
Lymphomas can be treated with radiation, chemotherapy or both: thanks to these treatments, refined in recent years, the chances of survival are significantly increased. However, the side effects caused by these therapies can also be very unpleasant and determine, for example, sterility.
The drug, however, is studying new, even more precise, innovative methods, only acts to defeat malignant cells without affecting healthy ones, in order to create the least possible side effects. Some research at defeat Lymphomas Perfect immunotherapy methods: these biological substances that can stimulate the body's immune system only for the destruction of affected lymphoma cells.

More info:

Medications for the treatment of non-Hodgkin's lymphoma

Drugs for the treatment of Hodgkin's lymphoma

Summary
To fix the concepts...

Disease

Lymphoma, a primary tumor of lymphoid cells (involving lymph nodes, glandular lymphatic system, T lymphocytes, B lymphocytes and precursors)

Impact

Very high incidence: the configuration among the most common malignant tumours worldwide; Lymphomas represent only 5% of malignant tumours, but also are the fifth cause of cancer deaths.

Because

For 70% of lymphomas, the cause is unknown; The remaining 30%, some lymphomas can be favored by an immune deficiency, autoimmune diseases, pathogens and viral infections.
Solar radiation and chemicals in general, are linked to neoplasms only 1% of cases

Lymphomas according to the classification and who REAL

Lymphoma of T lymphocyte precursors

Lymphoma of mature T lymphocytes and natural killer cells (e.g. leukemia for large granular lymphocytes T, lymphomatoid papulosis of Sèzaty syndrome)

Lymphoma

B cell precursors lymphoma (e.g. B cell precursors leukemia)

Lymphoma of mature lymphocytes B (e.g. follicular lymphoma, cutaneous lymphoma, mantle cell lymphoma)

Hodgkin's lymphoma where they belong: nodular sclerosis, cell depletion, cellular heterogeneity

Non-Hodgkin lymphomas (e.g. lymphoma rate)

Aggressive Lymphomas

indolent lymphomas

Clinical Evolution

Before the lymphoma remains circumscribed in a fork, then it spreads in two neighboring regions, can possibly metastasize.

Symptoms

Excessive weight loss, abundant sweating at night, high fever.

Possible therapies

Chemotherapy, radiotherapy.

Future Therapies

Immunotherapy that affects only cancerous cells and intact healthy leaves by reducing side effects.